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Pain and fatigue in rheumatoid arthritis can persist even after inflammation improves, with depression, poor sleep, obesity, smoking, and chronic pain potentially helping sustain symptoms. Researchers say identifying these hidden drivers could prevent unnecessary medication changes and lead to more personalized treatment.
A new analysis suggests mammograms may lead to far less breast cancer overdiagnosis than some earlier studies indicated. Researchers reexamined all eight major randomized screening trials and accounted for differences in follow-up time, screening frequency, and screening after trials ended. Their results were consistent with an overdiagnosis rate below 5%, rather than estimates approaching 30% to 50%.
Researchers found that scented cleaners can react with ozone indoors to create billions or trillions of invisible nanoparticles that can penetrate deep into the lungs. The pollution forms within minutes and, in some cases, may produce an inhaled particle dose comparable to or greater than standing near heavy traffic.
A major analysis suggests Phelan-McDermid syndrome, a genetic disorder closely linked to autism, may affect about 1 in 7,300 people and more than 45,000 Americans. Researchers warn that thousands of cases may remain hidden because genetic testing is often not performed, even as targeted treatments move into clinical trials.
Researchers have shown that exotic quantum particles called non-Abelian anyons can perform the full range of operations needed for universal quantum computing. Using 54 qubits on Quantinuum’s H2 processor, they combined braiding and fusion to unlock capabilities that braiding alone could not provide.
Researchers used CRISPR to remove CD33 from donor stem cells, potentially giving doctors a way to attack aggressive blood cancers without destroying the healthy cells patients need after a transplant. In a 30-patient trial, the edited cells successfully took hold and appeared to shield blood cells from a CD33-targeted cancer treatment.
A magnet-producing bacterium extended the average lifespan of C. elegans worms by more than 43% while helping protect their neurological and intestinal health. Researchers traced much of the effect to suppression of ferroptosis, a damaging form of cell death linked to iron buildup and oxidative stress.
A study shows chatbots mirror users' politics, part of a broader tendency known as AI sycophancy. Researchers fear this could deepen polarization.
Hubble observations of massive stars in metal-poor dwarf galaxies are revealing clues to why the early universe looks so unusual. Researchers found that stellar winds weaken sharply at extremely low metallicities, potentially allowing massive stars to retain more material and evolve in unexpected ways. The team also found large differences in iron abundance, a key ingredient in stellar winds and supernovae.
A newly identified breakdown in communication between nerves and muscles could help explain why people lose strength as they age. Researchers were able to improve muscle strength in an animal model by targeting a key protein, raising hopes that some age-related weakness could eventually be treated.
The brain may have a built-in way to quickly settle disagreements between regions processing the same scene. Researchers found that matching signals between two visual areas lasted longer, while conflicting signals rapidly faded away. This “consensus building” mechanism could help explain how the brain turns many specialized inputs into one unified view of the world.
A 70-year-old leukemia drug is still revealing new secrets. Researchers found that removing a protein called NUDT5 protected cells from the drug, even though simply blocking the protein had little effect. The unexpected result points to a hidden cellular role that could help explain why people respond differently to certain leukemia treatments.
Researchers have shown that multiple time crystals inside a semiconductor can synchronize their oscillations, much like pendulum clocks gradually falling into the same rhythm. The coupling is carried by spin-polarized electrons, allowing time crystals separated by up to 40 micrometers to lock to a common frequency. The discovery reveals surprisingly long-range connections between these exotic spin systems and could help researchers develop future spin-based devices.
A study shows chatbots mirror users' politics, part of a broader tendency known as AI sycophancy. Researchers fear this could deepen polarization.
The Cascadia subduction zone and northern San Andreas fault may sometimes rupture in rapid succession, according to evidence preserved in 3,100 years of ocean sediments. Researchers identified unusual sediment layers suggesting that earthquakes on the two systems have occurred just minutes to hours apart, including around the massive Cascadia earthquake of 1700. If such synchronization happened again, several major West Coast cities could face emergencies at nearly the same time.
Researchers observed a humpback whale mother staying beside her presumed stillborn calf for hours and possibly days off Australia’s Gold Coast. She maintained eye contact and remained close to the calf in behavior resembling caregiving and nurturing. Scientists say the rare observation may provide new insight into grief, maternal attachment, and emotional complexity in humpback whales.
Researchers have created a concrete mixture that is both stronger and capable of absorbing carbon dioxide. The best formula, combining zeolite with bamboo biochar, boosted compressive strength by 7.48% and tensile strength by 15% compared with conventional concrete. It also captured about 1.2 grams of CO₂ per day in laboratory testing.
Researchers have found evidence that long COVID may damage dopamine releasing neurons in the brain, potentially explaining persistent fatigue, low motivation, slowed movement, and memory difficulties. The discovery could lead to new treatments that target the brain's dopamine system.
A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point instead toward strategies such as balance and resistance exercise.
Ancient DNA reveals that plague repeatedly returned to Europe for more than 400 years after the Black Death, evolving into new lineages and spreading through trade, migration, and war. Researchers also developed a method to date ancient plague genomes more precisely, linking many of them to specific outbreaks recorded in historical sources.
