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Novo released new evidence that its experimental CagriSema injection can improve upon the weight loss with its blockbuster GLP-1 obesity injection, Wegovy.
Synthetic opioids like fentanyl are more powerful and in plentiful supply, and they have transformed the drugs landscape.
Scientists have discovered that a potential new drug can reverse severe fatty liver disease in animal models by restoring gut health and blocking harmful substances from reaching the liver. The breakthrough could pave the way for new treatments for liver disease and potentially other serious conditions, including cardiovascular disease.
The FDA has approved the first drug that directly targets Alexander disease, a devastating neurological disorder affecting fewer than one in a million people. Developed through decades of research, Zanvastro showed promising results in clinical trials, stabilizing motor function and even improving movement in some patients.
Researchers at Yale have identified a promising new approach to osteoarthritis that could do more than simply ease pain. The epilepsy drug lacosamide appears to block a protein involved in both pain signaling and cartilage destruction, helping damaged joints shift back toward repair in preclinical studies.
Blocking a receptor called P2X7 significantly reduced inflammation in human brain tissue, revealing a potential new treatment strategy for neurological and psychiatric disorders. The discovery could help researchers repurpose existing drugs for conditions including traumatic brain injury, Alzheimer’s, Parkinson’s, depression, and schizophrenia.
UN warns US boat strikes in the Caribbean counter-drug war may violate international law and human rights principles.
A vitamin D analog may help break down pancreatic cancer’s protective defenses, potentially making tumors more vulnerable to chemotherapy and immune attack. A small clinical trial found encouraging responses, especially in patients whose tumors had high levels of the vitamin D receptor.
Lenacapavir, a twice-a-year injection could transform HIV prevention, but it will not be available to all.
A topical drug that removes aging, damaged cells helped older mice heal skin wounds significantly faster. The treatment appeared to reactivate repair pathways involved in inflammation, collagen production, and new blood vessel growth.
A new experimental drug called CS18 may help break through cancer drug resistance by disabling several of the defenses tumors use to survive treatment. It strengthened existing therapies, restored drug sensitivity in resistant lung cancer cells, and slowed tumor growth in animal models.
More than 90 lawsuits against GLP-1 companies claim rare eye condition resulted from diabetes and weight loss drugs.
UN expert says US forces have killed 223 people in 68 attacks in the Caribbean and the Pacific in the past year.
A report says the attacks, of which there have been at least 68, were not self-defence.
Scientists are testing a counterintuitive way to fight mesothelioma, an aggressive asbestos-linked cancer with few effective treatments. A new experimental mesothelioma drug kills cancer cells by disabling PRX3, an antioxidant defense that tumors use to survive intense oxidative stress. In an early clinical trial, it controlled disease progression in 67% of patients and produced encouraging survival results, raising hopes that the strategy could eventually be used against other cancers.
In the annual report on organized crime, German police say cocaine is a danger for the state and society and cases of money laundering have increased.
